When I was living in Jacksonville, I worked with a woman who'd constantly say, "bless your heart" to me. At first I was all like, "Wow, she's just such a kind woman." Months later a friend I had made in town explained the real meaning behind the phrase. While, she didn't use the exact words that Hayden Panettiere used, it was along those lines.
WARNING: BLEEPED PROFANITY AHEAD